Publications:

•  Tulloch, I., Afanador, L., Mexhitaj, I., Ghazaryan, N., Garza, A. and Angulo, J. A. (2011) A single high dose of methamphetamine induces apoptotic and necrotic striatal cell loss lasting up to three months in mice, Neuroscience (in press).
• Wang, J. and Angulo, J. A. (2011) Synergism between methamphetamine and the neuropeptide substance P on the production of nitric oxide in the striatum of mice, Brain Research, 1369, 131-139.
• Wang, J. and Angulo, J. A. (2011) Methamphetamine induces striatal neurokinin-1 receptor endocytosis primarily in somatostatin/NPY/NOS interneurons and the role of dopamine receptors in mice, Synapse, 65, 300-308.
• Tulloch, I., Afanador, L., Zhu, J. Angulo, J. A. (2011) Methamphetamine induces striatal cell death followed by the generation of new cells and a second round of cell death in mice, J. Current Neuropharmacology, 9, 79-83.
•  Zhu, J., Xu, W., Wang, J., Ali, S. F. and Angulo, J. A. (2009) The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in mice, J. Neurochemistry, 111, 656-668.
• Wang, J., Xu, W., Ali, S. F. and Angulo, J. A. (2008) Connection between the striatal neurokinin-1 receptor and nitric oxide formation during methamphetamine exposure, Annals of the New York Academy of Sciences, 1139, 164-171.
• Zhu, J. P. Q., Xu, W. and Angulo, J. A. (2006) Distinct mechanisms mediating methamphetamine-induced neuronal apoptosis and dopamine terminal damage share the neuropeptide substance P in the striatum of mice, Annals of the New York Academy of Sciences, 1074, 135-148.
• Zhu, J. P. Q., Xu, W. and Angulo, J. A. (2006) Methamphetamine-induced cell death: Selective vulnerability in neuronal subpopulations of the striatum in mice, Neuroscience, 140, 607-622.
• Zhu, J. P. Q., Xu, W., Angulo, N. and Angulo, J. A. (2006) Methamphetamine-induced striatal apoptosis in the mouse brain: Comparison of a binge to an acute bolus drug administration, Neurotoxicology, 27, 131-136.
•  Zhu, J. P. Q., Xu, W. and Angulo, J. A. (2005) Disparity in the temporal appearance of methamphetamine-induced apoptosis and depletion of dopamine terminal markers in the striatum of mice, Brain Research, 1049:171-181.
• Xu, W., Zhu, J. P. Q. and Angulo, J. A. (2005) Induction of striatal pre- and postsynaptic damage by methamphetamine requires the dopamine receptors, Synapse, 58:110-121.
• Angulo, J. A., Angulo, N. and Yu, J. (2004) Antagonists of the neurokinin-1 or dopamine D1 receptors confer protection from methamphetamine on dopamine terminals of the mouse striatum., Ann. N. Y. Acad. Sci., 1025:171-180.
•  Yu, J., Wang, J., Cadet, J. L. and Angulo, J. A. (2004) Histological evidence supporting a role for the striatal neurokinin-1 receptor in methamphetamine-induced neurotoxicity in the mouse brain, Brain Research, 1007, 124-131.
•  Loonam, T, M., Noailles, P., Yu, J., Zhu, J., and Angulo, J. A., (2003) Substance P and Cholecystokinin Regulate Neurochemical Responses to Cocaine and Methamphetamine in the Striatum. Life Sciences 73:727-739.
•  Yu, J., Cadet, J. L. and Angulo, J. A., (2002) Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopamunergic neurotoxicity in the murine brain. J. Neurochemistry 83: 613-622.
• Wiedenmayer, C. P., Noailles, P., Angulo, J. A. and Gordon, B. A. (2002) Stress-induced enkephalin expression in the amygdala changes during early ontogeny in the rat, Neuroscience, 114:7-11.
• Noailles, P, and Angulo, J. A. (2002) Modulation of cocaine-evoked dopamine release by neurokinin-1 and 3 receptors in the striatum of the rat brain, Ann. N. Y. Acad. Sci., 965:267-273.
• Yu, J., Allison, S., Ibrahim, D., Cadet, J. L. and Angulo, J. A. (2002) Ontogeny of Neurokinin-1 receptor mediation of methamphetamine neurotoxicity in the striatum of the mouse brain, Ann. N. Y. Acad. Sci., 965:247-253.
• Kraft, M., Ahluwalia, S. and Angulo, J. A. (2001) Neurokinin-1 receptor antagonists block acute cocaine-induced horizontal locomotion, Ann. N. Y. Acad. Sci., 937:132-139.
• Kraft, M., Noailles, P. and Angulo, J. A. (2001) Substance P Modulates Cocaine-evoked Dopamine Overflow in the Striatum of the Rat Brain, Ann. N. Y. Acad. Sci., 937:121-131.
• Zhang, Y., Loonam, T., Noailles, P. and Angulo, J. A. (2001) Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic and early withdrawal, Ann. N. Y. Acad. Sci., 937:93-120.
• Segarra, A. C., Acosta, A. M., Gonzalez, J. L., Angulo, J. A. and McEwen, B. S. (1998) Sex differences in estrogenic regulation of preproenkephalin mRNA levels in the medial preoptic area of prepubertal rats, Molecular Brain Research 60:133-139.
•  Lucas, L. R., Angulo, J. A., Le Moal, M., McEwen, B. S. and Piazza, P. V. (1998) Neurochemical characterization of individual vulnerability to addictive drugs in rats, European Journal of Neuroscience. 10:3153-3163.
• Datta, U., Noailles, P.-A. H., Kraft, M., Zhang, Y. and Angulo, J. A. (1997) Concurrent elevation of the levels of expression of striatal preproenkephalin and preprodynorphin mRNA in the rat brain by chronic treatment with caffeine, Neuroscience Letters 231:29-31.
• Zhang, Y., Landas, K., Mueller, H. and Angulo, J. A. (1997) Progressive augmentation of striatal and accumbal preprotachykinin mRNA levels by chronic treatment with methamphetamine and effect of concurrent administration of the N-methyl-D-aspartate receptor antagonist MK-801, Neuropharmacology 36: 325-334.
• Datta, U., Noailles, P.-A. H., Rodriguez, M., Kraft, M., Zhang, Y. and Angulo, J. A. (1996) Accumulation of tyrosine hydroxylase messenger RNA molecules in the rat mesencephalon by chronic caffeine treatment, Neuroscience Letters 220: 77-80.
• Zhang, Y. and Angulo, J. A. (1996) Contrasting effects of repeated treatment vs withdrawal of methamphetamine on tyrosine hydroxylase messenger RNA levels in the ventral tegmental area and substantia nigra zona compacta of the rat brain, Synapse 24:218-223.
• Noailles, P.-A. H., Villegas, M., Ledoux, M., Lucas, L. R., McEwen, B. and Angulo, J. A. (1996) Acute treatment with the N-methyl-D-aspartate receptor antagonist MK-801: Effect of concurrent administration of haloperidol or scopolamine on preproenkephalin mRNA levels of the neostriatum of the rat brain, Neuroscience Letters, 202:165-168.
• Faina, R., Angulo, J. A., Luigi, P. and McEwen, B. (1995) Regulation of angiotensinogen gene expression in the rat forebrain by adrenal steroids and relation to salt appetite, Molecular Brain Research, 33:201-208.
• Villegas, M. and Angulo, J. (1995) Attenuation of Neostriatal preproenkephalin and preprotachykinin mRNA abundance after chronic treatment with the kainate/AMPA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione, Neuroscience Letters, 191:51-54.
• Angulo, J., Williams, A., Ledoux, M., Watanabe, Y. and McEwen, B. (1995) Elevation of striatal and accumbal proenkephalin, protachykinin and prodynorphin mRNA abundance subsequent to N-methyl-D-aspartate receptor blockade with MK801, Molecular Brain Research, 29:15-22.
• Angulo, J. (1994) Neuroleptic effects on neostriatal neuropeptide expression, in Stress Factors on Biological Systems and in Minority Populations. Grillo, C., Piroli, G., Gonzalez, S., Angulo, J., McEwen, B. and De Nicola, A. F. (1994) Glucocorticoid regulation of mRNA encoding (Na+K)ATPase alpha-3 and beta-1 subunits in rat brain measured by in situ hybridization, Brain Research, 657:83-91.
• Gonzalez, S., Grillo, C., De Nicola, A. G., Piroli, G., Angulo, J., McEwen, B. and De Nicola, A. (1994) Dexamethasone increases adrenalectomy-depressed (Na+K)ATPase mRNA and ouabain binding in spinal cord ventral horn, Journal of Nuerochemistry, 63:1962-1970.
• McEwen, B., Chao, H. and Angulo, J. (1994) Glucocorticoid and estrogen effects on the nigrostriatal and mesolimbic dopaminergic systems, in Trophic Regulation, pp67-88.
•  Angulo, J. and McEwen, B. (1994) Molecular aspects of neuropeptide regulation and function in the corpus striatum and nucleus accumbens, Brain Research Reviews, 19:1-28
• Pompei, P., Magarinos, A., Angulo, J. and McEwen, B. (1993) In situ hybridization analysis of preprotachykinin mRNAs in discrete brain areas of the rat brain: an involvement of tachykinins on sodium depletion-induced salt appetite, in Cellular Communication in Reproduction (Eds. Facchinetti, Henderson and Pierantoni-Magni) pp49-54.
• McEwen, B., Angulo, J., Gould, E., Mendelson, S. and Watanabe, Y. (1993) Antidepressant modulation of isolation and restraint stress effects on brain chemistry and morphology, European Psychiatry, 8:41s-48s.
• Angulo, J., Watanabe, Y., Cadet, J., Ledoux, M. and McEwen, B. (1993) Upregulation of forebrain proenkephalin mRNA subsequent to NMDA receptor blockade, European Journal of Pharmacology, 244:317-318.
• Zhu, S., Kujirai, K., Dollison, A., Angulo, J., Fahn, S. and Cadet, J. (1992) Implantation of genetically modified fetal cells into the rat striatum, Brain Research Bulletin, 29:81-93.
• McEwen, B., Angulo, J., Cameron, H., Chao, H., Gannon, M., Gould, E., Mendelson, S., Sakai, R., Spencer, R. and Woolley, C. (1992) Paradoxical effects of adrenal steroids on the brain: protection versus degeneration, Biological Psychiatry, 31:177-199.
• Angulo, J. (1992) Involvement of dopamine D1 and D2 receptors in the regulation of proenkephalin mRNA abundance in the striatum and accumbens of the rat brain, Journal of Neurochemistry, 58:1104-1109.
• Cadet, J., Zhu, Shu-ming, and Angulo, J. (1992) Quantitative in situ hybridization evidence for differential regulation of proenkephalin and dopamine D2 receptor mRNA levels in the rat striatum: effects of unilateral intrastriatal injections of 6-hydroxydopamine, Molecular Brain Research, 12:59-67.
• Cadet, J., Zhu, Shu-ming, Angulo, J. (1991) Intrastriatal implants of fetal mesencephalic cells attenuate the increases in striatal proenkephalin mRNA observed after unilateral 6-hydroxydopamine-induced lesions of the striatum, Brain Research Bulletin, 27:707-711.
• Angulo, J., Coirini, H., Ledoux, M. and Schumacher, M. (1991) Regulation by dopaminergic neurotransmission of dopamine D2 mRNA and receptor levels in the striatum and nucleus accumbens of the rat, Molecular Brain Research, 11:161-166.
• Grillo, C., Vallee, S., Piroli, G., Angulo, J., McEwen, B. and De Nicola, A. (1991) Effects of deoxycorticosterone treatment on beta-subunit mRNA for
• (Na-K)-ATPase in brain regions determined by in situ hybridization, Cellular and Molecular Neurobiology, 11:347-356.
• Angulo, J., Printz, D., Ledoux, M. and McEwen, B. (1991) Isolation stress increases tyrosine hydroxylase mRNA in the locus coeruleus and midbrain and decreases proenkephalin mRNA in the striatum and nucleus accumbens, Molecular Brain Research, 11:301-308.
• Angulo, J., Ledoux, M. and McEwen, B. (1991) Genomic effects of cold and isolation stress on magnocellular vasopressin mRNA-containing cells in the hypothalamus of the rat, Journal of Neurochemistry, 56:2033-2038.
• Yongue, B., Angulo, J., McEwen, B. and Myers, M. (1991) Angiotensinogen gene expression in brain and liver of spontaneously hypertensive and Wistar Kyoto rats, Hypertension, 17:485-491.
•  Angulo, J., Ledoux, M. and McEwen, B. (1991) Chronic treatment with pentazocine or SKF 10047 decrease proenkephalin mRNA levels in the rat striatum and nucleus accumbens, Neuroscience Letters, 122:47-49.
• Coirini, H., Schumacher, M., Angulo, J. and McEwen, B. (1990) Increase in striatal dopamine D2 receptor mRNA after lesions or haloperidol treatment, European Journal of Pharmacology, 186:369-371.
• Cadet, J., Angulo, J. and McEwen, B. (1990) Nerve Growth Factor (NGF) potentiates the changes in striatal proenkephalin mRNA subsequent to
• 6-hydroxydopamine-induced lesions of the substantia nigra, Brain Research Bulletin, 25:401-405.
• Angulo, J., Cadet, J. and McEwen, B. (1990) Effect of typical and atypical neuroleptic treatment on protachykinin mRNA levels in the striatum of the rat, Neuroscience Letters, 113:217-221.
• Angulo, J., Cadet, J. and McEwen, B. (1990) Sigma receptor blockade by BMY 14802 affects enkephalinergic and tachykinin cells differentially in the striatum of the rat, European Journal of Pharmacology, 175:225-228.
• Angulo, J., Cadet, J., Woolley, C., Suber, F. and McEwen, B. (1990) Effect of chronic typical and atypical neuroleptic treatment on proenkephalin mRNA levels in the striatum and nucleus accumbens of the rat, Journal of Neurochemistry, 54:1889-1894.
• Schulkin, J., Angulo, J., Sakai, R. and McEwen, B. (1989) The expression of salt hunger in intact and hypophysectomized rats, Neuroendocrinology,50:447-453.
• Angulo, J., Christoph, G., Manning, R., Burkhart, B. and Davis, L. (1987) Reduction of dopamine receptor activity differentially alters striatal neuropeptide mRNA levels, Advances in Experimental Medicine and Biology, 221:385-391.
• Angulo, J., Davis, L., Burkhart, B. and Christoph, G. (1987) Neuroleptic administration reduces the messenger RNA encoding substance P in striatum, in Substance P and Neurokinins, pp. 37-39, Springer-Verlag, New York.
• Angulo, J., Davis, L., Burkhart, B. and Christoph, G. (1986) Reduction of striatal dopaminergic neurotransmission elevates striatal proenkephalin mRNA, European Journal of Pharmacology, 130:341-343.
• Angulo, J. and Krakow, J. (1986) Sensitization of the Escherichia coli cyclic-AMP receptor protein to trypsin cleavage by polydeoxyribonucleotides and polyribonucleotides, Journal of Biological Chemistry, 261:11315-11319.
• Angulo, J. and Krakow, J. (1985) Effect of deoxyribopolymers on the sensitivity of the cyclic-AMP receptor protein of Escherichia coli to proteolytic attack, Archives of Biochemistry and Biophysics, 236:11-16.
• Angulo, J. (1986) Biochemical studies on the DNA binding function of the cyclic-AMP receptor protein of Escherichia coli, Doctoral Dissertation, City University of New York, University Microfilms, Ann Arbor, Michigan, pp 1-105